Extraído em Pubmed
Lima AC, Fregnani ER, Silva-Sousa YT, da Cruz Perez DE.
School of Dentistry, University of Ribeirao Preto (UNAERP), Ribeirao Preto, Sao Paulo Department of Stomatology, A. C. Camargo Hospital, Sao Paulo; Department of Clinical and Preventive Dentistry, Oral Pathology Section, Federal University of Pernambuco, Recife, Pernambuco, Brazil.
Parathyroid hormone/parathyroid hormone-related peptide receptor 1 (PTHR1) expression in odontogenic cystic lesions. International Endodontic Journal. ABSTRACT: Aim To evaluate parathyroid hormone/parathyroid hormone-related peptide receptor 1 (PTHR1) expression in odontogenic cystic lesions and to compare immunoexpression between the lesions. Methodology Thirty-five radicular cysts, 22 dentigerous cysts and 17 keratocystic odontogenic tumours were evaluated. Immunohistochemical reactions against PHTR1 were carried out in 3-μm histological sections, and the expression and the intensity of PTHR1 expression were evaluated. For statistical analysis, the Fisher exact test was used, with a significance of 5%. Results The intensity of expression in the epithelial lining was significantly weaker in the radicular cyst (P = 0.007). However, in the fibrous capsule, the radicular cyst presented higher positivity for PTHR1 (P = 0.04). Conclusions The probable co-expression of PTHrP and PTHR1 in odontogenic cystic lesions may eventually have an autocrine and/or paracrine stimulus in the epithelial and mesenchymal cells, inducing proliferation and lesion growth.
© 2011 International Endodontic Journal.